T2D-Db contains the information related to molecular factors involved in the pathogenesis of Type 2 Diabetes in Human, Mouse and Rat. Currently T2D-Db compiles the following informations that are related to Type 2 Diabetes:

         In T2D-Db, the search options are almost common in many of the sections which facilitate the users to retrieve the required information efficiently. The common search options are:

         Enter a keyword which can be NCBI Gene ID, Gene Symbol, Gene Name, Gene Alias, etc. that are applicable for each section. Examples are given for each type of query. A list of hits separately for each organism that matches with the query will appear in the result page.

        Select any one organism name such as Human, Mouse or Rat from the drop down menu. A list of gene symbols corresponding to the user selected organism will appear. Now select a gene or genes (press ctrl or shift key to select more than one gene) of interest from the drop down menu and submit.

        Select any one organism name such as Human, Mouse or Rat from the drop down menu to view its entire corresponding gene list.

         In Compact view “View Compact Information” option, a precise description about the gene with NCBI Gene ID, Gene symbol, Gene name and Gene locus are provided.

        In Detailed view option, along with the information in compact view, OMIM ID, Ensembl ID and NCBI Gene ID with links to its respective databases, Gene summary and Gene symbol are available.

         Gene symbol which has a link to T2D-Db contains informations such as candidate genes, Gene aliases, Links to External Databases, Pathways, Protein-Protein Interaction, Gene Ontology, Gene Orthologs, SNP Marker Information and Literature.

        Use the “check box” to select and click “Save Selected Information” option. The results will be saved in a text file.

        Go to SNP Browse in T2D-Db and then click “Search by Chromosomal position”. Now select an organism and a corresponding chromosome number using drop down menu. Enter the start and end position of chromosomal and click “View Marker Map”.

        T2D-Db provides information about the protein-protein interaction of Type 2 diabetes gene candidates. In protein-protein interaction section of T2D-Db, user can browse using different search options available such as Search by keyword, Search by Gene symbol(s) and browse protein-protein interaction.

        In Data view, informations about the interactors with external link to corresponding databases are provided. Cytoscape, a network visualization and analysis software is integrated in Network view of T2D-Db facilitating the graphical view of the protein interactors as a network.

        In ‘Gene Expression Search’ section, two modes of search options are available to browse for the microarray expression data such as ‘Search by Experiments’ and ‘Search by Genes across multiple experiments’. In the first search mode, options are provided in drop down menu for selecting the organism, experiment (GEO accession number along with reference) and the gene(s) of interest whereas in the second search mode, the option to select the experiment is not provided so that the microarray expression data for the selected genes will be displayed for all the experiments in the result page. Probe set ID and expression levels in different samples and control are made available in the results. User can select the genes using drop down menu to view its respective heat map by clicking on the option ‘Select gene(s) to view Heat map’.

        Tissue specific expression information can be searched using the options ‘Search by Gene symbol(s)’ or ‘Search by tissue(s)’ in ‘Tissue Specific Expression’ section of T2D-Db.

        EST data can be searched using the options ‘Search by keyword’, ‘Search by Gene symbol(s)’ or ‘Browse EST data’ in EST information section of T2D-Db. The result page provides a list of EST IDs for the selected genes which are externally linked to dbEST database.